Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene
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چکیده
منابع مشابه
Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
The identification of molecular networks at the system level in mammals is accelerated by next-generation mammalian genetics without crossing, which requires both the efficient production of whole-body biallelic knockout (KO) mice in a single generation and high-performance phenotype analyses. Here, we show that the triple targeting of a single gene using the CRISPR/Cas9 system achieves almost ...
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Copyright: © 2006 Julie Ahringer and contributors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. To whom correspondence should be addressed. E-mail: [email protected] Reverse genetics* Julie Ahringer, e...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2016
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2015.12.052